By the early 1960s, Brandon's population was 8,000, and it was estimated that one new family moved into town every day. Brandon began spreading out into the bordering communities of Limona, Seffner, and Valrico; Hopewell Road became four lanes wide and was designated State Road 60. Soon, the town's first shopping center, Brandon Center, was built, and Brooker Elementary School and the Brandon Swim and Tennis Club both opened in 1965. In the next few years, Kingswood Elementary School, the Brandon Public Library, and many housing developments, shopping centers, and golf courses further fueled or reflected the influx of new residences and businesses.

By the 1970s, growth was causing traffic congestion, as approximately 430 commercial and service businesses, 3 malls and a population of 40,000 were all contained within a six-mile (10 km) radius.

In the mid-1970s, Hillsborough Community College moved to Brandon by holding classes at public schools. More indications of the increasing population were the building of Brandon Community Hospital and the Brandon Cultural Center (now the Center Place Fine Arts and Civic Association).

Brandon took off rapidly during the 1980s. Development of the southern area of Brandon brought thousands of new residents. On September 27, 1986, I-75 began to bring traffic through the Brandon area, dramatically changing the community and helping its population reach approximately 100,000 with over 2,500 business by 1988.